Epigenetically mediated gene silencing [electronic resource] : a companion to genetic alterations in driving tumorigenesis / Stephen Baylin.
Material type:
FilmSeries: Henry Stewart talksBiomedical & life sciences collection. Epigenetics : concepts, theories, paradigms and mechanisms: Publisher: London : Henry Stewart Talks, 2007Description: 1 online resource (1 streaming video file (68 min.) : color, sound)Other title: Epigenetically mediated gene silencing : tumorigenesisSubject(s): Epigenesis, Genetic | Gene Expression Regulation, Neoplastic | Gene SilencingOnline resources: Click here to access online | Series Animated audio-visual presentation with synchronized narration.
Title from title frames.
Contents: Introduction to epigenetic changes in cancer -- defining the process of promoter DNA hypermethylation as a constituent of a broad range of chromatin abnormalities in cancer -- defining the genes aberrantly silenced in cancer including approaches being used to screen the cancer genome for such genes -- defining what is known about the interaction of DNA methylation and chromatin modifications for initiating and maintaining gene silencing in cancer -- outlining the position of aberrant gene silencing in tumor progression and particularly highlighting the key role these changes may play for the earliest steps in tumorigenesis -- defining the potential for using DNA hypermethylated gene promoter sequences as molecular markers for cancer risk assessment, early diagnosis and prognosis -- discussing the possibilities for targeting reversal of gene silencing as a prevention and therapeutic strategy for cancer.
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Mode of access: World Wide Web.