Baylin, Stephen B.
Epigenetically mediated gene silencing a companion to genetic alterations in driving tumorigenesis / [electronic resource] : Epigenetically mediated gene silencing : tumorigenesis Stephen Baylin. - London : Henry Stewart Talks, 2007. - 1 online resource (1 streaming video file (68 min.) : color, sound). - Epigenetics : concepts, theories, paradigms and mechanisms, 2056-452X . - Henry Stewart talks. Biomedical & life sciences collection. Epigenetics : concepts, theories, paradigms and mechanisms. .
Animated audio-visual presentation with synchronized narration. Title from title frames.
Contents: Introduction to epigenetic changes in cancer -- defining the process of promoter DNA hypermethylation as a constituent of a broad range of chromatin abnormalities in cancer -- defining the genes aberrantly silenced in cancer including approaches being used to screen the cancer genome for such genes -- defining what is known about the interaction of DNA methylation and chromatin modifications for initiating and maintaining gene silencing in cancer -- outlining the position of aberrant gene silencing in tumor progression and particularly highlighting the key role these changes may play for the earliest steps in tumorigenesis -- defining the potential for using DNA hypermethylated gene promoter sequences as molecular markers for cancer risk assessment, early diagnosis and prognosis -- discussing the possibilities for targeting reversal of gene silencing as a prevention and therapeutic strategy for cancer.
Access restricted to subscribers.
Mode of access: World Wide Web.
1038 Henry Stewart Talks
Epigenesis, Genetic.
Gene Expression Regulation, Neoplastic.
Gene Silencing.
Epigenetically mediated gene silencing a companion to genetic alterations in driving tumorigenesis / [electronic resource] : Epigenetically mediated gene silencing : tumorigenesis Stephen Baylin. - London : Henry Stewart Talks, 2007. - 1 online resource (1 streaming video file (68 min.) : color, sound). - Epigenetics : concepts, theories, paradigms and mechanisms, 2056-452X . - Henry Stewart talks. Biomedical & life sciences collection. Epigenetics : concepts, theories, paradigms and mechanisms. .
Animated audio-visual presentation with synchronized narration. Title from title frames.
Contents: Introduction to epigenetic changes in cancer -- defining the process of promoter DNA hypermethylation as a constituent of a broad range of chromatin abnormalities in cancer -- defining the genes aberrantly silenced in cancer including approaches being used to screen the cancer genome for such genes -- defining what is known about the interaction of DNA methylation and chromatin modifications for initiating and maintaining gene silencing in cancer -- outlining the position of aberrant gene silencing in tumor progression and particularly highlighting the key role these changes may play for the earliest steps in tumorigenesis -- defining the potential for using DNA hypermethylated gene promoter sequences as molecular markers for cancer risk assessment, early diagnosis and prognosis -- discussing the possibilities for targeting reversal of gene silencing as a prevention and therapeutic strategy for cancer.
Access restricted to subscribers.
Mode of access: World Wide Web.
1038 Henry Stewart Talks
Epigenesis, Genetic.
Gene Expression Regulation, Neoplastic.
Gene Silencing.