Mapping small molecule binding sites with phage display technology (Record no. 78389)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02325ngm a2200337 a 4500 |
| 001 - CONTROL NUMBER | |
| control field | HST1717_1_2 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | UkLoHST |
| 006 - FIXED-LENGTH DATA ELEMENTS--ADDITIONAL MATERIAL CHARACTERISTICS | |
| fixed length control field | m c |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION | |
| fixed length control field | cr|cna|||a|||| |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION | |
| fixed length control field | vz|czazum |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 080121s2008 enk|||||||||||s|||v|eng d |
| 028 50 - PUBLISHER NUMBER | |
| Publisher number | 1717 |
| Source | Henry Stewart Talks |
| 035 ## - SYSTEM CONTROL NUMBER | |
| System control number | (UkLoHST)948 |
| 035 ## - SYSTEM CONTROL NUMBER | |
| System control number | (UkLU-K)AC000393605 |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | UkLU-K |
| Language of cataloging | eng |
| Transcribing agency | UkLU-K |
| 100 1# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Makowski, Lee. |
| Relator code | spk |
| 245 10 - TITLE STATEMENT | |
| Title | Mapping small molecule binding sites with phage display technology |
| Medium | [electronic resource] / |
| Statement of responsibility, etc. | Lee Makowski. |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) | |
| Place of publication, distribution, etc. | London : |
| Name of publisher, distributor, etc. | Henry Stewart Talks, |
| Date of publication, distribution, etc. | 2008. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 1 online resource (1 streaming video file (39 min.) : |
| Other physical details | color, sound). |
| 490 1# - SERIES STATEMENT | |
| Series statement | Chemical biology : the role of chemistry in our fundamental understanding of biology, |
| International Standard Serial Number | 2056-452X |
| 500 ## - GENERAL NOTE | |
| General note | Animated audio-visual presentation with synchronized narration. |
| 500 ## - GENERAL NOTE | |
| General note | Title from title frames. |
| 505 0# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | Contents: How do you identify the molecular target of a small molecule drug? -- Flexible regions are key players -- P-loop of ATP-binding proteins is an important example -- Can display libraries of flexible peptides on proteins select those that bind to the ligand -- Selection is through an affinity process called biopanning -- Success depends on the diversity of the library -- Diversity depends on how many different peptides are in the library and their relative abundance -- RELIC can be used to calculate the diversity of a library from the sequences of ~100 peptides -- Identification of motifs from a population is easy if the motif is very strong -- Taxol-binding peptides were also identified by phage display and those peptides were used to identify the position on tubulin where taxol is bound and to identify Bcl-2 as a taxolbinding protein -- Significant data from a variety of sources argue that the taxol-Bcl-2 interaction is important to the clinical efficacy of taxol. |
| 506 ## - RESTRICTIONS ON ACCESS NOTE | |
| Terms governing access | Access restricted to subscribers. |
| 538 ## - SYSTEM DETAILS NOTE | |
| System details note | Mode of access: World Wide Web. |
| 650 #2 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Biology. |
| 650 #2 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Chemistry. |
| 830 #0 - SERIES ADDED ENTRY--UNIFORM TITLE | |
| Uniform title | Henry Stewart talks. |
| Name of part/section of a work | Biomedical & life sciences collection. |
| -- | Chemical biology : the role of chemistry in our fundamental understanding of biology. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://hstalks.com/bs/948/">https://hstalks.com/bs/948/</a> |
| 856 42 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://hstalks.com/bs/p/279/">https://hstalks.com/bs/p/279/</a> |
| Materials specified | Series |
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