Regulation of blood coagulation by the serpin, antithrombin [electronic resource] / Steven T. Olson.
Material type:![Film](/opac-tmpl/lib/famfamfam/VM.png)
Animated audio-visual presentation with synchronized narration.
Title from title frames.
Contents: Antithrombin and hemostasis -- Dysfunctional antithrombins and thrombophilia -- Protease regulation by serpins -- Heparin requirement for antithrombin function -- Structural determinants of heparin binding to antithrombin -- Heparin-induced conformational changes in antithrombin -- Heparin as an allosteric activator of antithrombin -- Bridging and conformational change mechanisms of heparin activation of antithrombin -- Structural basis of conformational activation -- Role of exosites in conformational activation -- Role of the reactive loop in antithrombin anticoagulant function -- Implications for improved heparin anticoagulants.
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Mode of access: World Wide Web.