Olson, Steven T.
Regulation of blood coagulation by the serpin, antithrombin [electronic resource] / Steven T. Olson. - London : Henry Stewart Talks, 2007. - 1 online resource (1 streaming video file (48 min.) : color, sound). - Protein epidemiology : understanding human diseases at the level of protein structure and function, 2056-452X . - Henry Stewart talks. Biomedical & life sciences collection. Protein epidemiology. .
Animated audio-visual presentation with synchronized narration. Title from title frames.
Contents: Antithrombin and hemostasis -- Dysfunctional antithrombins and thrombophilia -- Protease regulation by serpins -- Heparin requirement for antithrombin function -- Structural determinants of heparin binding to antithrombin -- Heparin-induced conformational changes in antithrombin -- Heparin as an allosteric activator of antithrombin -- Bridging and conformational change mechanisms of heparin activation of antithrombin -- Structural basis of conformational activation -- Role of exosites in conformational activation -- Role of the reactive loop in antithrombin anticoagulant function -- Implications for improved heparin anticoagulants.
Access restricted to subscribers.
Mode of access: World Wide Web.
1384 Henry Stewart Talks
Antithrombins.
Hemostasis.
Protein Conformation.
Proteins.
Serpins.
Regulation of blood coagulation by the serpin, antithrombin [electronic resource] / Steven T. Olson. - London : Henry Stewart Talks, 2007. - 1 online resource (1 streaming video file (48 min.) : color, sound). - Protein epidemiology : understanding human diseases at the level of protein structure and function, 2056-452X . - Henry Stewart talks. Biomedical & life sciences collection. Protein epidemiology. .
Animated audio-visual presentation with synchronized narration. Title from title frames.
Contents: Antithrombin and hemostasis -- Dysfunctional antithrombins and thrombophilia -- Protease regulation by serpins -- Heparin requirement for antithrombin function -- Structural determinants of heparin binding to antithrombin -- Heparin-induced conformational changes in antithrombin -- Heparin as an allosteric activator of antithrombin -- Bridging and conformational change mechanisms of heparin activation of antithrombin -- Structural basis of conformational activation -- Role of exosites in conformational activation -- Role of the reactive loop in antithrombin anticoagulant function -- Implications for improved heparin anticoagulants.
Access restricted to subscribers.
Mode of access: World Wide Web.
1384 Henry Stewart Talks
Antithrombins.
Hemostasis.
Protein Conformation.
Proteins.
Serpins.