Mitochondrial and lysosomal dysfunction in the pathogenesis of Parkinson's disease [electronic resource] / A.H.V. Schapira.
Material type:
FilmSeries: Henry Stewart talksBiomedical & life sciences collection. Parkinson's disease: Publisher: London : Henry Stewart Talks, 2014Description: 1 online resource (1 streaming video file (35 min.) : color, sound)Subject(s): Lysosomes -- Metabolism | Mitochondrial pathology | Parkinson's disease -- Pathogenesis | DNA, Mitochondrial | Gaucher Disease | Lysosomes -- metabolism | Lysosomes -- pathology | Mitochondria -- metabolism | Mitochondria -- pathology | Mitochondrial Degradation | Mitochondrial Diseases | Parkinson Disease -- metabolism | Parkinson Disease -- pathology | Parkinson Disease -- physiopathologyOnline resources: Click here to access online | Series Animated audio-visual presentation with synchronized narration.
Title from title frames.
Contents: Pathogenesis of Parkinson's disease (PD) -- Mitochondria (biochemistry, DNA, proteins, turnover) -- Oxidative phosphorylation and respiratory chain -- Fraction of deleted mtDNA in substantia nigra (SN) -- Mitochondrial complex I deficiency in PD -- PARK loci -- The role of mitophagy in mitochondrial turnover -- Common pathways underlying PD pathogenesis -- Ageing and PD pathogenesis -- Autosomal mitochondrial diseases -- POLG mutations -- Alpha-synuclein (SNCA) and mitochondria -- Autophagy, lysosomal dysfunction and Glucocerebrosidase (GCase) -- Gaucher disease -- Chaperone-mediated autophagy: LAMP-2A -- GBA mutations -- DAT density and disease progression in PD -- DaTScan in genetic PD -- GCase-SNCA as a target for PD -- GBA & GBA-SNCA pathway as targets for PD therapies.
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Mode of access: World Wide Web.