Schapira, Anthony H. V.
Mitochondrial and lysosomal dysfunction in the pathogenesis of Parkinson's disease [electronic resource] / A.H.V. Schapira. - London : Henry Stewart Talks, 2014. - 1 online resource (1 streaming video file (35 min.) : color, sound). - Parkinson's disease, 2056-452X . - Henry Stewart talks. Biomedical & life sciences collection. Parkinson's disease. .
Animated audio-visual presentation with synchronized narration. Title from title frames.
Contents: Pathogenesis of Parkinson's disease (PD) -- Mitochondria (biochemistry, DNA, proteins, turnover) -- Oxidative phosphorylation and respiratory chain -- Fraction of deleted mtDNA in substantia nigra (SN) -- Mitochondrial complex I deficiency in PD -- PARK loci -- The role of mitophagy in mitochondrial turnover -- Common pathways underlying PD pathogenesis -- Ageing and PD pathogenesis -- Autosomal mitochondrial diseases -- POLG mutations -- Alpha-synuclein (SNCA) and mitochondria -- Autophagy, lysosomal dysfunction and Glucocerebrosidase (GCase) -- Gaucher disease -- Chaperone-mediated autophagy: LAMP-2A -- GBA mutations -- DAT density and disease progression in PD -- DaTScan in genetic PD -- GCase-SNCA as a target for PD -- GBA & GBA-SNCA pathway as targets for PD therapies.
Access restricted to subscribers.
Mode of access: World Wide Web.
3812 Henry Stewart Talks
Lysosomes--Metabolism.
Mitochondrial pathology.
Parkinson's disease--Pathogenesis.
DNA, Mitochondrial.
Gaucher Disease.
Lysosomes--metabolism.
Lysosomes--pathology.
Mitochondria--metabolism.
Mitochondria--pathology.
Mitochondrial Degradation.
Mitochondrial Diseases.
Parkinson Disease--metabolism.
Parkinson Disease--pathology.
Parkinson Disease--physiopathology.
Mitochondrial and lysosomal dysfunction in the pathogenesis of Parkinson's disease [electronic resource] / A.H.V. Schapira. - London : Henry Stewart Talks, 2014. - 1 online resource (1 streaming video file (35 min.) : color, sound). - Parkinson's disease, 2056-452X . - Henry Stewart talks. Biomedical & life sciences collection. Parkinson's disease. .
Animated audio-visual presentation with synchronized narration. Title from title frames.
Contents: Pathogenesis of Parkinson's disease (PD) -- Mitochondria (biochemistry, DNA, proteins, turnover) -- Oxidative phosphorylation and respiratory chain -- Fraction of deleted mtDNA in substantia nigra (SN) -- Mitochondrial complex I deficiency in PD -- PARK loci -- The role of mitophagy in mitochondrial turnover -- Common pathways underlying PD pathogenesis -- Ageing and PD pathogenesis -- Autosomal mitochondrial diseases -- POLG mutations -- Alpha-synuclein (SNCA) and mitochondria -- Autophagy, lysosomal dysfunction and Glucocerebrosidase (GCase) -- Gaucher disease -- Chaperone-mediated autophagy: LAMP-2A -- GBA mutations -- DAT density and disease progression in PD -- DaTScan in genetic PD -- GCase-SNCA as a target for PD -- GBA & GBA-SNCA pathway as targets for PD therapies.
Access restricted to subscribers.
Mode of access: World Wide Web.
3812 Henry Stewart Talks
Lysosomes--Metabolism.
Mitochondrial pathology.
Parkinson's disease--Pathogenesis.
DNA, Mitochondrial.
Gaucher Disease.
Lysosomes--metabolism.
Lysosomes--pathology.
Mitochondria--metabolism.
Mitochondria--pathology.
Mitochondrial Degradation.
Mitochondrial Diseases.
Parkinson Disease--metabolism.
Parkinson Disease--pathology.
Parkinson Disease--physiopathology.