Lentiviral vectors [electronic resource] : design, biological properties, milestones and current major applications, hazards. Part 1 of 2 / Luigi Naldini.
Material type:
FilmSeries: Henry Stewart talksBiomedical & life sciences collection. Gene transfer and gene therapy: Publisher: London : Henry Stewart Talks, 2014Description: 1 online resource (1 streaming video file (58 min.) : color, sound)Other title: Lentiviral vectors : design, biological properties, milestones and current major applications, hazards, part 1 of 2Subject(s): Gene therapy | Genetic transformation | Genetic vectors | Lentiviruses | Medical genetics | Viral genetics | Gene Transfer Techniques | Genetic Therapy -- methods | Genetic Vectors -- genetics | Genetic Vectors -- toxicity | Genetics, Medical | Genome, Viral | HIV Infections | HIV-1 | Lentivirus -- genetics | Mutagenesis, Insertional | Retroviridae -- genetics | Virus Integration -- geneticsOnline resources: Click here to access online | Series Animated audio-visual presentation with synchronized narration.
Title from title frames.
Contents: Properties of retroviral vectors: Genetic stability in target cells, Transgene expression, Fidelity of replication, Target cell spectrum, Transdution efficiency, Toxicity, RCR or WT virus contamination, Integration, Immunogenicity -- Innate immune recognition of retroviral vectors -- Lentiviral vectors -- Nuclear import of viral genome -- Challenges of developing lentiviral vectors -- Viral vector design -- Design of HIV-based vectors -- Third generation lentiviral vectors -- Lentiviral vector composition -- Lentiviral gene transfer -- Reducing HIV content of packaging system -- Self-inactivating transfer vectors -- HIV vector transcription in HIV-1 infected cells -- Lentiviral vector biosafety -- Lentiviral vectors: risk of insertional mutagenesis.
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Mode of access: World Wide Web.