Naldini, Luigi,
Lentiviral vectors design, biological properties, milestones and current major applications, hazards. Part 1 of 2 / [electronic resource] : Lentiviral vectors : design, biological properties, milestones and current major applications, hazards, part 1 of 2 Luigi Naldini. - London : Henry Stewart Talks, 2014. - 1 online resource (1 streaming video file (58 min.) : color, sound). - Gene transfer and gene therapy, 2056-452X . - Henry Stewart talks. Biomedical & life sciences collection. Gene transfer and gene therapy. .
Animated audio-visual presentation with synchronized narration. Title from title frames.
Contents: Properties of retroviral vectors: Genetic stability in target cells, Transgene expression, Fidelity of replication, Target cell spectrum, Transdution efficiency, Toxicity, RCR or WT virus contamination, Integration, Immunogenicity -- Innate immune recognition of retroviral vectors -- Lentiviral vectors -- Nuclear import of viral genome -- Challenges of developing lentiviral vectors -- Viral vector design -- Design of HIV-based vectors -- Third generation lentiviral vectors -- Lentiviral vector composition -- Lentiviral gene transfer -- Reducing HIV content of packaging system -- Self-inactivating transfer vectors -- HIV vector transcription in HIV-1 infected cells -- Lentiviral vector biosafety -- Lentiviral vectors: risk of insertional mutagenesis.
Access restricted to subscribers.
Mode of access: World Wide Web.
3805 Henry Stewart Talks
Gene therapy.
Genetic transformation.
Genetic vectors.
Lentiviruses.
Medical genetics.
Viral genetics.
Gene Transfer Techniques.
Genetic Therapy--methods.
Genetic Vectors--genetics.
Genetic Vectors--toxicity.
Genetics, Medical.
Genome, Viral.
HIV Infections.
HIV-1.
Lentivirus--genetics.
Mutagenesis, Insertional.
Retroviridae--genetics.
Virus Integration--genetics.
Lentiviral vectors design, biological properties, milestones and current major applications, hazards. Part 1 of 2 / [electronic resource] : Lentiviral vectors : design, biological properties, milestones and current major applications, hazards, part 1 of 2 Luigi Naldini. - London : Henry Stewart Talks, 2014. - 1 online resource (1 streaming video file (58 min.) : color, sound). - Gene transfer and gene therapy, 2056-452X . - Henry Stewart talks. Biomedical & life sciences collection. Gene transfer and gene therapy. .
Animated audio-visual presentation with synchronized narration. Title from title frames.
Contents: Properties of retroviral vectors: Genetic stability in target cells, Transgene expression, Fidelity of replication, Target cell spectrum, Transdution efficiency, Toxicity, RCR or WT virus contamination, Integration, Immunogenicity -- Innate immune recognition of retroviral vectors -- Lentiviral vectors -- Nuclear import of viral genome -- Challenges of developing lentiviral vectors -- Viral vector design -- Design of HIV-based vectors -- Third generation lentiviral vectors -- Lentiviral vector composition -- Lentiviral gene transfer -- Reducing HIV content of packaging system -- Self-inactivating transfer vectors -- HIV vector transcription in HIV-1 infected cells -- Lentiviral vector biosafety -- Lentiviral vectors: risk of insertional mutagenesis.
Access restricted to subscribers.
Mode of access: World Wide Web.
3805 Henry Stewart Talks
Gene therapy.
Genetic transformation.
Genetic vectors.
Lentiviruses.
Medical genetics.
Viral genetics.
Gene Transfer Techniques.
Genetic Therapy--methods.
Genetic Vectors--genetics.
Genetic Vectors--toxicity.
Genetics, Medical.
Genome, Viral.
HIV Infections.
HIV-1.
Lentivirus--genetics.
Mutagenesis, Insertional.
Retroviridae--genetics.
Virus Integration--genetics.