Use of isolated populations in disease gene identification [electronic resource] / Leena Peltonen.
Material type:
FilmSeries: Henry Stewart talksBiomedical & life sciences collection. Genetic epidemiology II : latest developments: Publisher: London : Henry Stewart Talks, 2007Description: 1 online resource (1 streaming video file (54 min.) : color, sound)Other title: Use of isolated populations : pitfalls and potentialSubject(s): Genetic Predisposition to Disease -- epidemiologyOnline resources: Click here to access online | Series Animated audio-visual presentation with synchronized narration.
Title from title frames.
Contents: Disease mutations in Finland - Molecular background of Finnish disease heritage - Finnish disease genes, novel pathways exposed - Example: APECED - AIRE protein - AIRE regulates ectopic expression in thymus - AIRE deficiency - Simplifying the complex genetic background of common diseases - Advantages of isolated populations - Internal isolates: increased genetic homogeneity - Lactose intolerance - Adult type hypolactasia - Severe coronary heart disease - Familial combined hyperlipidemia, FCHL - USF1: a transcription factor - Effect of genetic association on target cells, coronary wall and impact in population - Population based cohorts in Finland - Global effort is needed.
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Mode of access: World Wide Web.