Peltonen, Leena.
Use of isolated populations in disease gene identification [electronic resource] / Use of isolated populations : pitfalls and potential Leena Peltonen. - London : Henry Stewart Talks, 2007. - 1 online resource (1 streaming video file (54 min.) : color, sound). - Genetic epidemiology II : latest developments, 2056-452X . - Henry Stewart talks. Biomedical & life sciences collection. Genetic epidemiology II : latest developments. .
Animated audio-visual presentation with synchronized narration. Title from title frames.
Contents: Disease mutations in Finland - Molecular background of Finnish disease heritage - Finnish disease genes, novel pathways exposed - Example: APECED - AIRE protein - AIRE regulates ectopic expression in thymus - AIRE deficiency - Simplifying the complex genetic background of common diseases - Advantages of isolated populations - Internal isolates: increased genetic homogeneity - Lactose intolerance - Adult type hypolactasia - Severe coronary heart disease - Familial combined hyperlipidemia, FCHL - USF1: a transcription factor - Effect of genetic association on target cells, coronary wall and impact in population - Population based cohorts in Finland - Global effort is needed.
Access restricted to subscribers.
Mode of access: World Wide Web.
1819 Henry Stewart Talks
Genetic Predisposition to Disease--epidemiology.
Use of isolated populations in disease gene identification [electronic resource] / Use of isolated populations : pitfalls and potential Leena Peltonen. - London : Henry Stewart Talks, 2007. - 1 online resource (1 streaming video file (54 min.) : color, sound). - Genetic epidemiology II : latest developments, 2056-452X . - Henry Stewart talks. Biomedical & life sciences collection. Genetic epidemiology II : latest developments. .
Animated audio-visual presentation with synchronized narration. Title from title frames.
Contents: Disease mutations in Finland - Molecular background of Finnish disease heritage - Finnish disease genes, novel pathways exposed - Example: APECED - AIRE protein - AIRE regulates ectopic expression in thymus - AIRE deficiency - Simplifying the complex genetic background of common diseases - Advantages of isolated populations - Internal isolates: increased genetic homogeneity - Lactose intolerance - Adult type hypolactasia - Severe coronary heart disease - Familial combined hyperlipidemia, FCHL - USF1: a transcription factor - Effect of genetic association on target cells, coronary wall and impact in population - Population based cohorts in Finland - Global effort is needed.
Access restricted to subscribers.
Mode of access: World Wide Web.
1819 Henry Stewart Talks
Genetic Predisposition to Disease--epidemiology.