Systemic RNA interference (RNAi) therapeutics for the treatment of HIV-1 [electronic resource] / John Rossi.
Material type:
FilmSeries: Henry Stewart talksBiomedical & life sciences collection. Antivirals: Publisher: London : Henry Stewart Talks, 2014Description: 1 online resource (1 streaming video file (38 min.) : color, sound)Subject(s): Antiviral agents | Gene therapy | HIV infections -- Treatment | Small interfering RNA -- Therapeutic use | Acquired Immunodeficiency Syndrome -- drug therapy | Anti-HIV Agents -- therapeutic use | Genetic Therapy | HIV Infections -- drug therapy | HIV-1 -- drug effects | Molecular Targeted Therapy | RNA Interference | RNA, Small Interfering -- therapeutic useOnline resources: Click here to access online | Series Animated audio-visual presentation with synchronized narration.
Title from title frames.
Contents: Systemic RNA interference (RNAi): Therapeutics for the treatment of HIV-1 -- HIV life cycle -- Typical Course of HIV infection -- Why do we need new HIV drugs? -- Major goals of anti-HIV therapies -- Combinatorial RNA based therapy for HIV -- Applying RNAi for the treatment of human diseases -- treat HIV infection by systemic delivery of small RNAs -- Aptamers -- Chimeric-siRNA aptamer uptake into gp120 expressing cells -- Aptamer-targeted RNA interference for HIV-1 therapy -- Aptamer and aptamer chimera mediated inhibition of HIV-1 -- Small animal model for studying anti-HIV RNAi based therapies -- Both aptamer and aptamer chimera inhibit HIV infection -Aptamer and chimeric aptamer-siRNA prevent CD4+ cell decline -- Aptamer and dsiRNAS effect on viral load -- Flexible PAMAM dendrimers with a triethanolamine core -- Dendrimers plus siRNAs form nanoparticles, protect siRNA from degradation and deliver siRNAs to T-lymphocytes -- G5 dendrimer delivered siRNAs down regulate target mRNAs in vitro -- Multiplex siRNAs for HIV-1 treatment -- In vivo analyses of G5 dendrimer delivered siRNAs -- Reductions in HIV loads following dendrimer siRNA injections -- Dendrimer-siRNA complexes protect HIV infected RAG-hu mice from CD4 T cell loss -- Bio distribution of G5 dendrimer siRNAs.
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Mode of access: World Wide Web.