Systemic RNA interference (RNAi) therapeutics for the treatment of HIV-1 (Record no. 77103)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03030ngm a2200445 a 4500 |
| 001 - CONTROL NUMBER | |
| control field | HST3250 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | UkLoHST |
| 006 - FIXED-LENGTH DATA ELEMENTS--ADDITIONAL MATERIAL CHARACTERISTICS | |
| fixed length control field | m c |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION | |
| fixed length control field | cr|cna|||a|||| |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION | |
| fixed length control field | vz|czazum |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 140422s2014 enk|||||||||||s|||v|eng d |
| 028 50 - PUBLISHER NUMBER | |
| Publisher number | 3250 |
| Source | Henry Stewart Talks |
| 035 ## - SYSTEM CONTROL NUMBER | |
| System control number | (UkLoHST)2659 |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | UkLoHST |
| Language of cataloging | eng |
| Transcribing agency | UkLoHST |
| 100 1# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Rossi, John, |
| Affiliation | (Beckman Research Institute of the City of Hope, USA) |
| Relator code | spk |
| 245 10 - TITLE STATEMENT | |
| Title | Systemic RNA interference (RNAi) therapeutics for the treatment of HIV-1 |
| Medium | [electronic resource] / |
| Statement of responsibility, etc. | John Rossi. |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) | |
| Place of publication, distribution, etc. | London : |
| Name of publisher, distributor, etc. | Henry Stewart Talks, |
| Date of publication, distribution, etc. | 2014. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 1 online resource (1 streaming video file (38 min.) : |
| Other physical details | color, sound). |
| 490 1# - SERIES STATEMENT | |
| Series statement | Antivirals : latest developments and future progress, |
| International Standard Serial Number | 2056-452X |
| 500 ## - GENERAL NOTE | |
| General note | Animated audio-visual presentation with synchronized narration. |
| 500 ## - GENERAL NOTE | |
| General note | Title from title frames. |
| 505 0# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | Contents: Systemic RNA interference (RNAi): Therapeutics for the treatment of HIV-1 -- HIV life cycle -- Typical Course of HIV infection -- Why do we need new HIV drugs? -- Major goals of anti-HIV therapies -- Combinatorial RNA based therapy for HIV -- Applying RNAi for the treatment of human diseases -- treat HIV infection by systemic delivery of small RNAs -- Aptamers -- Chimeric-siRNA aptamer uptake into gp120 expressing cells -- Aptamer-targeted RNA interference for HIV-1 therapy -- Aptamer and aptamer chimera mediated inhibition of HIV-1 -- Small animal model for studying anti-HIV RNAi based therapies -- Both aptamer and aptamer chimera inhibit HIV infection -Aptamer and chimeric aptamer-siRNA prevent CD4+ cell decline -- Aptamer and dsiRNAS effect on viral load -- Flexible PAMAM dendrimers with a triethanolamine core -- Dendrimers plus siRNAs form nanoparticles, protect siRNA from degradation and deliver siRNAs to T-lymphocytes -- G5 dendrimer delivered siRNAs down regulate target mRNAs in vitro -- Multiplex siRNAs for HIV-1 treatment -- In vivo analyses of G5 dendrimer delivered siRNAs -- Reductions in HIV loads following dendrimer siRNA injections -- Dendrimer-siRNA complexes protect HIV infected RAG-hu mice from CD4 T cell loss -- Bio distribution of G5 dendrimer siRNAs. |
| 506 ## - RESTRICTIONS ON ACCESS NOTE | |
| Terms governing access | Access restricted to subscribers. |
| 538 ## - SYSTEM DETAILS NOTE | |
| System details note | Mode of access: World Wide Web. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Antiviral agents. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Gene therapy. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | HIV infections |
| General subdivision | Treatment. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Small interfering RNA |
| General subdivision | Therapeutic use. |
| 650 #2 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Acquired Immunodeficiency Syndrome |
| General subdivision | drug therapy. |
| 650 #2 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Anti-HIV Agents |
| General subdivision | therapeutic use. |
| 650 #2 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Genetic Therapy. |
| 650 #2 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | HIV Infections |
| General subdivision | drug therapy. |
| 650 #2 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | HIV-1 |
| General subdivision | drug effects. |
| 650 #2 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Molecular Targeted Therapy. |
| 650 #2 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | RNA Interference. |
| 650 #2 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | RNA, Small Interfering |
| General subdivision | therapeutic use. |
| 830 #0 - SERIES ADDED ENTRY--UNIFORM TITLE | |
| Uniform title | Henry Stewart talks. |
| Name of part/section of a work | Biomedical & life sciences collection. |
| -- | Antivirals. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://hstalks.com/bs/2659/">https://hstalks.com/bs/2659/</a> |
| 856 42 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://hstalks.com/bs/p/613/">https://hstalks.com/bs/p/613/</a> |
| Materials specified | Series |
No items available.