Quantitative analysis of receptor allosterism and its implication for drug discovery [electronic resource] / Rumin Zhang.
Material type: FilmSeries: Henry Stewart talksBiomedical & life sciences collection: Publisher: London : Henry Stewart Talks, 2015Description: 1 online resource (1 streaming video file (57 min.) : color, sound)Subject(s): Cell receptors | Drug development | Drug receptors | Pharmaceutical chemistry | Drug Agonism | Drug Discovery | Receptors, Cytoplasmic and Nuclear | Receptors, G-Protein-Coupled -- agonists | Receptors, G-Protein-Coupled -- chemistryOnline resources: Click here to access onlineAnimated audio-visual presentation with synchronized narration.
Title from title frames.
Contents: G protein-coupled receptors (GPCRs) -- Receptor agonism and allosterism -- Orthosteric and allosteric binders -- Inverse, partial and full agonists -- Positive, silent and negative allosteric modulators (PAMs, SAMs and NAMs) -- Allosteric two-state model and general operational model with constitutive receptor activity -- Optimal design of experiment -- Global curve fitting analysis of affinity and efficacy parameters -- Beta supremacy -- Monte Carlo simulations.
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Mode of access: World Wide Web.