Zhang, Rumin,
Quantitative analysis of receptor allosterism and its implication for drug discovery [electronic resource] / Rumin Zhang. - London : Henry Stewart Talks, 2015. - 1 online resource (1 streaming video file (57 min.) : color, sound). - The biomedical & life sciences collection, 2056-452X . - Henry Stewart talks. Biomedical & life sciences collection. .
Animated audio-visual presentation with synchronized narration. Title from title frames.
Contents: G protein-coupled receptors (GPCRs) -- Receptor agonism and allosterism -- Orthosteric and allosteric binders -- Inverse, partial and full agonists -- Positive, silent and negative allosteric modulators (PAMs, SAMs and NAMs) -- Allosteric two-state model and general operational model with constitutive receptor activity -- Optimal design of experiment -- Global curve fitting analysis of affinity and efficacy parameters -- Beta supremacy -- Monte Carlo simulations.
Access restricted to subscribers.
Mode of access: World Wide Web.
4030 Henry Stewart Talks
Cell receptors.
Drug development.
Drug receptors.
Pharmaceutical chemistry.
Drug Agonism.
Drug Discovery.
Receptors, Cytoplasmic and Nuclear.
Receptors, G-Protein-Coupled--agonists.
Receptors, G-Protein-Coupled--chemistry.
Quantitative analysis of receptor allosterism and its implication for drug discovery [electronic resource] / Rumin Zhang. - London : Henry Stewart Talks, 2015. - 1 online resource (1 streaming video file (57 min.) : color, sound). - The biomedical & life sciences collection, 2056-452X . - Henry Stewart talks. Biomedical & life sciences collection. .
Animated audio-visual presentation with synchronized narration. Title from title frames.
Contents: G protein-coupled receptors (GPCRs) -- Receptor agonism and allosterism -- Orthosteric and allosteric binders -- Inverse, partial and full agonists -- Positive, silent and negative allosteric modulators (PAMs, SAMs and NAMs) -- Allosteric two-state model and general operational model with constitutive receptor activity -- Optimal design of experiment -- Global curve fitting analysis of affinity and efficacy parameters -- Beta supremacy -- Monte Carlo simulations.
Access restricted to subscribers.
Mode of access: World Wide Web.
4030 Henry Stewart Talks
Cell receptors.
Drug development.
Drug receptors.
Pharmaceutical chemistry.
Drug Agonism.
Drug Discovery.
Receptors, Cytoplasmic and Nuclear.
Receptors, G-Protein-Coupled--agonists.
Receptors, G-Protein-Coupled--chemistry.