Protein degradation and defense against neurodegenerative disease [electronic resource] : part 1 of 2 / Alfred Goldberg.
Material type:
FilmSeries: Henry Stewart talksBiomedical & life sciences collection. Protein homeostasis: Publisher: London : Henry Stewart Talks, 2014Description: 1 online resource (1 streaming video file (39 min.) : color, sound)Other title: Protein degradation and defense against neurodegenerative disease, part 1 of 2Subject(s): Brain -- Aging -- Molecular aspects | Nervous system -- Degeneration | Protein folding | Proteins -- Metabolism | Ubiquitin | Heat-Shock Proteins | Homeostasis | Lewy Bodies | Ligases | Neurodegenerative Diseases -- metabolism | Proteasome Endopeptidase Complex | Protein Folding | Proteins -- chemistry | Proteins -- metabolism | Proteolysis | Ubiquitin -- metabolismOnline resources: Click here to access online | Series Animated audio-visual presentation with synchronized narration.
Title from title frames.
Contents: Neurodegenerative diseases with inclusion bodies associated with ubiquitin and proteasomes -- Abnormal proteins rapidly degraded in cells -- The ubiquitin-proteasome pathway -- Ubiquitin ligases important in neurological disease -- CHIP, Hsp70 and Hsp90 -- Conditions that induce muscle wasting -- Ubiquitin ligases in muscles atrophy -- P97/VCP -- Autophagy -- The Nedd4 ubiquitin-ligase and α-Synuclein -- The ESCRT pathway -- Proteasomal VS. lysosomal degradation (K48 and K63-linked chains) -- Expression of Nedd4 in Lewy bodies.
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Mode of access: World Wide Web.