Cellular cofactors of HIV integrase [electronic resource] : from target identification to discovery of LEDGINs / Zeger Debyser.
Material type: FilmSeries: Henry Stewart talksBiomedical & life sciences collection. Antivirals: Publisher: London : Henry Stewart Talks, 2021Description: 1 online resource (1 streaming video file (52 min.) : color, sound)Subject(s): Antiviral agents | Drug Development | HIV (Viruses) -- Enzymes -- Inhibitors | HIV infections -- Treatment | Antiviral Agents -- pharmacology | Drug Discovery | HIV Infections -- drug therapy | HIV Integrase -- metabolism | HIV -- drug effects | Intercellular Signaling Peptides and Proteins | lens epithelium-derived growth factor | transportin SR2Online resources: Click here to access online | SeriesAnimated audio-visual presentation with synchronized narration.
Title from title frames.
Updated version of a talk first published in 2011.
Contents: Cellular cofactors of HIV as novel antiviral targets -- LEDGF/p75 is a tethering factor of HIV integrase -- Identification of LEDGF/p75 as binding partner of integrase -- Characterization of the interaction -- Validation of integrase -- LEDGF/p75 interaction as antiviral target -- Assay and Drug Development -- Transportin -- SR2 is a nuclear import factor.
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Mode of access: World Wide Web.