Metabolic and biochemical alterations in Alzheimer's disease [electronic resource] : facts and fictions / Mark A. Smith.
Material type:
FilmSeries: Henry Stewart talksBiomedical & life sciences collection. Alzheimer's disease: Publisher: London : Henry Stewart Talks, 2011Description: 1 online resource (1 streaming video file (51 min.) : color, sound)Subject(s): Alzheimer's disease | Alzheimer Disease -- metabolismOnline resources: Click here to access online | Series Animated audio-visual presentation with synchronized narration.
Title from title frames.
Contents: What causes selective neuronal loss in AD? -- Tauist and BAPtist hypothesis of AD -- Pathology and oxidative stress relationship -- NFT and amyloid-beta -- Stress-activated protein kinases and phospho-tau -- Amyloid-targeted approaches are unsuccessful -- Amyloid-beta controls redox activity -- Genetic factors are related to oxidative stress -- Therapeutics -- Potential mechanism of ROS generation -- Oxidative modifications and macromolecules -- Oxidative damage directly correlates with mtDNA -- Abnormal mitochondrial distribution in AD brains -- Iron histochemistry -- Antioxidant diet is protective -- Only one non-amyloid drug in phase III: 2010 -- Oxidative stress is necessary but not sufficient -- CaMKII-MYC mice -- Oxidative stress and cell cycle abnormalities -- Early stages of AD disease signals.
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Mode of access: World Wide Web.