RAS and RAF signaling in melanoma [electronic resource] : biology and therapies / Richard Marais.
Material type: FilmSeries: Henry Stewart talksBiomedical & life sciences collection. Protein phosphorylation: Publisher: London : Henry Stewart Talks, 2010Description: 1 online resource (1 streaming video file (37 min.) : color, sound)Other title: RAS and RAF signalling in melanomaSubject(s): Genes, ras | Melanoma -- therapy | Neoplasm Proteins | Proto-Oncogene Proteins B-raf | Signal TransductionOnline resources: Click here to access online | SeriesAnimated audio-visual presentation with synchronized narration.
Title from title frames.
Contents: Melanoma -- BRAF and RAS mutated in approximately 70% of cases -- Mouse models of melanoma -- Oncogenic BRAF can be a founder mutation in melanoma -- Mouse models replicate human disease -- BRAF inhibitors induce paradoxical activation of CRAF and drive pathway activation -- Kinase-dead BRAF mimics this and potentiates RAS ooncogenesis -- BRAF inhibitors induce excellent responses in patients, but may induce mechanism-based side effects through CRAF.
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Mode of access: World Wide Web.