Marais, Richard,
RAS and RAF signaling in melanoma biology and therapies / [electronic resource] : RAS and RAF signalling in melanoma Richard Marais. - London : Henry Stewart Talks, 2010. - 1 online resource (1 streaming video file (37 min.) : color, sound). - Protein phosphorylation, 2056-452X . - Henry Stewart talks. Biomedical & life sciences collection. Protein phosphorylation. .
Animated audio-visual presentation with synchronized narration. Title from title frames.
Contents: Melanoma -- BRAF and RAS mutated in approximately 70% of cases -- Mouse models of melanoma -- Oncogenic BRAF can be a founder mutation in melanoma -- Mouse models replicate human disease -- BRAF inhibitors induce paradoxical activation of CRAF and drive pathway activation -- Kinase-dead BRAF mimics this and potentiates RAS ooncogenesis -- BRAF inhibitors induce excellent responses in patients, but may induce mechanism-based side effects through CRAF.
Access restricted to subscribers.
Mode of access: World Wide Web.
2684 Henry Stewart Talks
Genes, ras.
Melanoma--therapy.
Neoplasm Proteins.
Proto-Oncogene Proteins B-raf.
Signal Transduction.
RAS and RAF signaling in melanoma biology and therapies / [electronic resource] : RAS and RAF signalling in melanoma Richard Marais. - London : Henry Stewart Talks, 2010. - 1 online resource (1 streaming video file (37 min.) : color, sound). - Protein phosphorylation, 2056-452X . - Henry Stewart talks. Biomedical & life sciences collection. Protein phosphorylation. .
Animated audio-visual presentation with synchronized narration. Title from title frames.
Contents: Melanoma -- BRAF and RAS mutated in approximately 70% of cases -- Mouse models of melanoma -- Oncogenic BRAF can be a founder mutation in melanoma -- Mouse models replicate human disease -- BRAF inhibitors induce paradoxical activation of CRAF and drive pathway activation -- Kinase-dead BRAF mimics this and potentiates RAS ooncogenesis -- BRAF inhibitors induce excellent responses in patients, but may induce mechanism-based side effects through CRAF.
Access restricted to subscribers.
Mode of access: World Wide Web.
2684 Henry Stewart Talks
Genes, ras.
Melanoma--therapy.
Neoplasm Proteins.
Proto-Oncogene Proteins B-raf.
Signal Transduction.