SH2-containing PTPs (Shps) in RTK signaling and disease [electronic resource] / Benjamin G. Neel.
Material type:
FilmSeries: Henry Stewart talksBiomedical & life sciences collection. Signal transduction via protein tyrosine kinase receptors : structures, function, regulation, mechanisms and role in disease: Publisher: London : Henry Stewart Talks, 2007Description: 1 online resource (1 streaming video file (60 min.) : color, sound)Other title: Src homology 2-containing Protein Tyrosine Phosphatases (Shps) in Receptor Protein-Tyrosine Kinase signaling and diseaseSubject(s): Receptor Protein-Tyrosine Kinases | Signal TransductionOnline resources: Click here to access online | Series Animated audio-visual presentation with synchronized narration.
Title from title frames.
Contents: Introduction to the PTP superfamily -- Shps, history and overview -- Shp stucture: role of SH2 domains, PTP domains, C-tail -- catalytic mechanism -- Regulation by phosphotyrosyl peptides, phosphorylation, reactive oxygen species -- Overview of physiological functions -- Role in RTK signaling: regulation of Ras/Erk pathway; roles in other downstream cascades -- Shps in disease -- Key questions and challenges for the future.
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Mode of access: World Wide Web.