Receptor tyrosine kinases [electronic resource] : function, families and evolution / Tony Hunter.
Material type:
FilmSeries: Henry Stewart talksBiomedical & life sciences collection. Signal transduction via protein tyrosine kinase receptors : structures, function, regulation, mechanisms and role in disease: ; Henry Stewart talksBiomedical & life sciences collection. World of hormones : molecular and physiological insights: Publisher: London : Henry Stewart Talks, 2007Description: 1 online resource (1 streaming video file (53 min.) : color, sound)Subject(s): Hormones | Receptor Protein-Tyrosine Kinases | Signal TransductionOnline resources: Click here to access online | Series (Signal transduction) | Series (World of hormones) Animated audio-visual presentation with synchronized narration.
Title from title frames.
Contents: History of protein phosphorylation -- Protein kinase bioinformatics -- History of tyrosine phosphorylation and functions of tyrosine kinases -- Genomic catalogues of protein kinases (kinomes) -- The human kinome -- The evolution of kinomes -- The human tyrosine kinase subfamily -- Receptor and nonreceptor tyrosine kinases -- Activation of receptor tyrosine kinases by ligand-induced dimerization -- Signal transduction pathways downstream of receptor tyrosine kinases -- Insulin and IOGF-1 receptor signaling via the mTOR pathway -- mTOR-S6 kinase feedback loop leading to downregulation of the IRS1 docking protein and insulin resistance -- History of Eph receptor tyrosine kinases and their ephrin ligands -- Bidirectional signaling via Eph-ephrin interactions on neighboring cells -- Simultaneous signaling by EphAs and ephrin As in motor neurons -- Compartmentalized signaling by receptor tyrosine kinases and their ligands through localization to discrete membrane domains -- Protein kinases and human disease -- Human cancer genes and protein kinases -- Protein kinases and phosphatases and cancer -- The long road to Gleevec.
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Mode of access: World Wide Web.