PI3K/AKT signaling In cancer [electronic resource] / Neal Rosen.
Material type:
FilmSeries: Henry Stewart talksBiomedical & life sciences collection. Protein phosphorylation: Publisher: London : Henry Stewart Talks, 2011Description: 1 online resource (1 streaming video file (68 min.) : color, sound)Subject(s): Cancer -- Pathophysiology | Cellular signal transduction | Protein-tyrosine kinase -- Inhibitors | Neoplasms -- physiopathology | Phosphatidylinositol 3-Kinase | Proto-Oncogene Proteins c-akt | Signal Transduction -- physiologyOnline resources: Click here to access online | Series Animated audio-visual presentation with synchronized narration.
Title from title frames.
Contents: PI3K/AKT signal transduction pathway -- Tumors with frequent dysregulation of PI3K signalling -- Modalities for inhibiting PI3K-AKT signaling currently in development -- AKT1/2 inhibitor (Merck) -- PI3K/AKT in breast cancer -- AKTi-1/2 inhibits AKT signaling and causes G1 arrest -- The Herceptin-resistant -- Effect of AKT inhibition on glucose levels -- Mutated elements in mitogenic signaling pathways in tumors -- Coexistent K-Ras or B-Raf mutation -- Genes encoding several components of mitogenic signaling pathways are mutationally activated in tumors -- Integrators of multiple signaling pathways (OR-gates) -- The effects of combined inhibition of AKT and MAPK on the phosphorylation of translational regulatory proteins -- Knockdown of 4EBP1 expression -- Feedback inhibition of insulin/IGF-1 signaling -- The concept of feedback -- Clinical effects of Rapamycin-like drugs -- mTORC1 vs. AKT regulated feedback -- Clinical uses of AKT inhibitors.
Access restricted to subscribers.
Mode of access: World Wide Web.