Cross-genomic analysis of human disease genes [electronic resource] / Ethan Bier.
Material type:
FilmSeries: Henry Stewart talksBiomedical & life sciences collection. Legacy of Drosophila genetics : from 'defining the gene' to 'analyzing genome function': Publisher: London : Henry Stewart Talks, 2008Description: 1 online resource (1 streaming video file (65 min.) : color, sound)Subject(s): Drosophila -- geneticsOnline resources: Click here to access online | Series Animated audio-visual presentation with synchronized narration.
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Contents: Systematic cross genomic comparison revealed that 75% of human disease genes have clear homologs in Drosophila and that approx. 30% are highly conserved sequences -- The fly is an excellent model multicellular organism for examining the mechanistic function of conserved human disease genes involved in developmental or tissue-related processes -- Normal or mutant human disease genes can be mis-expressed in the fly in localized patterns or at specific times using the GAL4-UAS mis-expression system -- Flies were used to identify candidate target proteins that are regulated by Ube3a and may contribute to Angelman syndrome -- Flies were used to examine the function and interaction of two toxins, Lethal Factor (LF) and Edema Factor (EF), that are produced by Bacillus anthracis -- LF cleaves at least two of the four Drosophila MAPKKs and inhibits the function of a third -- EF inhibits PKA dependent Hedgehog signaling in the fly wing.
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Mode of access: World Wide Web.