Cross-genomic analysis of human disease genes (Record no. 78435)
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000 -LEADER | |
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fixed length control field | 02256ngm a2200325 a 4500 |
001 - CONTROL NUMBER | |
control field | HST1780_1_3 |
003 - CONTROL NUMBER IDENTIFIER | |
control field | UkLoHST |
006 - FIXED-LENGTH DATA ELEMENTS--ADDITIONAL MATERIAL CHARACTERISTICS | |
fixed length control field | m c |
007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION | |
fixed length control field | cr|cna|||a|||| |
007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION | |
fixed length control field | vz|czazum |
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
fixed length control field | 080121s2008 enk|||||||||||s|||v|eng d |
028 50 - PUBLISHER NUMBER | |
Publisher number | 1780 |
Source | Henry Stewart Talks |
035 ## - SYSTEM CONTROL NUMBER | |
System control number | (UkLoHST)987 |
035 ## - SYSTEM CONTROL NUMBER | |
System control number | (UkLU-K)000947359 |
040 ## - CATALOGING SOURCE | |
Original cataloging agency | UkLU-K |
Language of cataloging | eng |
Transcribing agency | UkLU-K |
100 1# - MAIN ENTRY--PERSONAL NAME | |
Personal name | Bier, Ethan. |
Relator code | spk |
245 10 - TITLE STATEMENT | |
Title | Cross-genomic analysis of human disease genes |
Medium | [electronic resource] / |
Statement of responsibility, etc. | Ethan Bier. |
260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) | |
Place of publication, distribution, etc. | London : |
Name of publisher, distributor, etc. | Henry Stewart Talks, |
Date of publication, distribution, etc. | 2008. |
300 ## - PHYSICAL DESCRIPTION | |
Extent | 1 online resource (1 streaming video file (65 min.) : |
Other physical details | color, sound). |
490 1# - SERIES STATEMENT | |
Series statement | The legacy of Drosophila genetics : from 'defining the gene' to 'analyzing genome function', |
International Standard Serial Number | 2056-452X |
500 ## - GENERAL NOTE | |
General note | Animated audio-visual presentation with synchronized narration. |
500 ## - GENERAL NOTE | |
General note | Title from title frames. |
505 0# - FORMATTED CONTENTS NOTE | |
Formatted contents note | Contents: Systematic cross genomic comparison revealed that 75% of human disease genes have clear homologs in Drosophila and that approx. 30% are highly conserved sequences -- The fly is an excellent model multicellular organism for examining the mechanistic function of conserved human disease genes involved in developmental or tissue-related processes -- Normal or mutant human disease genes can be mis-expressed in the fly in localized patterns or at specific times using the GAL4-UAS mis-expression system -- Flies were used to identify candidate target proteins that are regulated by Ube3a and may contribute to Angelman syndrome -- Flies were used to examine the function and interaction of two toxins, Lethal Factor (LF) and Edema Factor (EF), that are produced by Bacillus anthracis -- LF cleaves at least two of the four Drosophila MAPKKs and inhibits the function of a third -- EF inhibits PKA dependent Hedgehog signaling in the fly wing. |
506 ## - RESTRICTIONS ON ACCESS NOTE | |
Terms governing access | Access restricted to subscribers. |
538 ## - SYSTEM DETAILS NOTE | |
System details note | Mode of access: World Wide Web. |
650 #2 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
Topical term or geographic name as entry element | Drosophila |
General subdivision | genetics. |
830 #0 - SERIES ADDED ENTRY--UNIFORM TITLE | |
Uniform title | Henry Stewart talks. |
Name of part/section of a work | Biomedical & life sciences collection. |
-- | Legacy of Drosophila genetics : from 'defining the gene' to 'analyzing genome function'. |
856 40 - ELECTRONIC LOCATION AND ACCESS | |
Uniform Resource Identifier | <a href="https://hstalks.com/bs/987/">https://hstalks.com/bs/987/</a> |
856 42 - ELECTRONIC LOCATION AND ACCESS | |
Uniform Resource Identifier | <a href="https://hstalks.com/bs/p/283/">https://hstalks.com/bs/p/283/</a> |
Materials specified | Series |
No items available.