Fitness and compensation [electronic resource] / Sébastian Gagneux.
Material type:![Film](/opac-tmpl/lib/famfamfam/VM.png)
Animated audio-visual presentation with synchronized narration.
Title from title frames.
Contents: Concept of Darwinian fitness -- Understanding the fitness impact of drug resistance -- Mathematical models -- Reversal of drug resistance in bacteria -- How to measure fitness -- The molecular epidemiology approach -- Effect of drug resistance mutations -- Environment effects on fitness measurements -- Effect of strain genetic background -- Pre-adapted strain "families" -- Biogeography of M. tuberculosis -- Compensatory evolution -- Experimental evidence -- Compensation prevents reversion to drug sensitivity -- Types of compensatory mutations -- Questions for future research -- Comparative genomics.
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Mode of access: World Wide Web.