Gagneux, Sébastian.
Fitness and compensation [electronic resource] / Sébastian Gagneux. - London : Henry Stewart Talks, 2009. - 1 online resource (1 streaming video file (34 min.) : color, sound). - Antibiotic resistance : from genes to global prevalence, 2056-452X . - Henry Stewart talks. Biomedical & life sciences collection. Antibiotic resistance : from genes to global prevalence. .
Animated audio-visual presentation with synchronized narration. Title from title frames.
Contents: Concept of Darwinian fitness -- Understanding the fitness impact of drug resistance -- Mathematical models -- Reversal of drug resistance in bacteria -- How to measure fitness -- The molecular epidemiology approach -- Effect of drug resistance mutations -- Environment effects on fitness measurements -- Effect of strain genetic background -- Pre-adapted strain "families" -- Biogeography of M. tuberculosis -- Compensatory evolution -- Experimental evidence -- Compensation prevents reversion to drug sensitivity -- Types of compensatory mutations -- Questions for future research -- Comparative genomics.
Access restricted to subscribers.
Mode of access: World Wide Web.
2548 Henry Stewart Talks
Drug Resistance, Microbial.
Fitness and compensation [electronic resource] / Sébastian Gagneux. - London : Henry Stewart Talks, 2009. - 1 online resource (1 streaming video file (34 min.) : color, sound). - Antibiotic resistance : from genes to global prevalence, 2056-452X . - Henry Stewart talks. Biomedical & life sciences collection. Antibiotic resistance : from genes to global prevalence. .
Animated audio-visual presentation with synchronized narration. Title from title frames.
Contents: Concept of Darwinian fitness -- Understanding the fitness impact of drug resistance -- Mathematical models -- Reversal of drug resistance in bacteria -- How to measure fitness -- The molecular epidemiology approach -- Effect of drug resistance mutations -- Environment effects on fitness measurements -- Effect of strain genetic background -- Pre-adapted strain "families" -- Biogeography of M. tuberculosis -- Compensatory evolution -- Experimental evidence -- Compensation prevents reversion to drug sensitivity -- Types of compensatory mutations -- Questions for future research -- Comparative genomics.
Access restricted to subscribers.
Mode of access: World Wide Web.
2548 Henry Stewart Talks
Drug Resistance, Microbial.