Fitness and compensation [electronic resource] / Sébastian Gagneux.
Material type:
FilmSeries: Henry Stewart talksBiomedical & life sciences collection. Antibiotic resistance : from genes to global prevalence: Publisher: London : Henry Stewart Talks, 2009Description: 1 online resource (1 streaming video file (34 min.) : color, sound)Subject(s): Drug Resistance, MicrobialOnline resources: Click here to access online | Series Animated audio-visual presentation with synchronized narration.
Title from title frames.
Contents: Concept of Darwinian fitness -- Understanding the fitness impact of drug resistance -- Mathematical models -- Reversal of drug resistance in bacteria -- How to measure fitness -- The molecular epidemiology approach -- Effect of drug resistance mutations -- Environment effects on fitness measurements -- Effect of strain genetic background -- Pre-adapted strain "families" -- Biogeography of M. tuberculosis -- Compensatory evolution -- Experimental evidence -- Compensation prevents reversion to drug sensitivity -- Types of compensatory mutations -- Questions for future research -- Comparative genomics.
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Mode of access: World Wide Web.