Arginase and nitric oxide [electronic resource] / Peter J. Murray.
Material type:
FilmSeries: Henry Stewart talksBiomedical & life sciences collection. Innate immunity : host recognition and response in health and disease: Publisher: London : Henry Stewart Talks, 2011Description: 1 online resource (1 streaming video file (39 min.) : color, sound)Subject(s): Arginase | Natural immunity | Nitric oxide | arginase I, human | Arginase | Arginine | Immunity, Innate | Macrophages | Nitric Oxide Synthase Type II | Nitric Oxide | NOS2 protein, humanOnline resources: Click here to access online | Series Animated audio-visual presentation with synchronized narration.
Title from title frames.
Updated version of a talk first published in 2009.
Contents: Catabolism of arginine to downstream substrates -- Catabolism of arginine in macrophages -- Nitric oxide production -- Control of iNOS at the transcriptional level -- Role of nitric oxide in immunity to intracellular pathogens with a focus on mycobacterial disease -- Structure of arginases -- Transcriptional control of arginase 1 in the liver vs. macrophages -- Arginases can suppress nitric oxide production by substrate depletion -- Pathogens use many mechanisms to regulate nitric oxide -- Arginases and alternatively-activated macrophages (AAMs) -- Schistosome infection as an example of AAM function -- AAMs and arginases -- Arginase inhibition by small molecules -- Outstanding questions.
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Mode of access: World Wide Web.