Regulation of blood coagulation by the serpin, antithrombin [electronic resource] / Steven T. Olson.
Material type:
FilmSeries: Henry Stewart talksBiomedical & life sciences collection. Protein epidemiology: Publisher: London : Henry Stewart Talks, 2007Description: 1 online resource (1 streaming video file (48 min.) : color, sound)Subject(s): Antithrombins | Hemostasis | Protein Conformation | Proteins | SerpinsOnline resources: Click here to access online | Series Animated audio-visual presentation with synchronized narration.
Title from title frames.
Contents: Antithrombin and hemostasis -- Dysfunctional antithrombins and thrombophilia -- Protease regulation by serpins -- Heparin requirement for antithrombin function -- Structural determinants of heparin binding to antithrombin -- Heparin-induced conformational changes in antithrombin -- Heparin as an allosteric activator of antithrombin -- Bridging and conformational change mechanisms of heparin activation of antithrombin -- Structural basis of conformational activation -- Role of exosites in conformational activation -- Role of the reactive loop in antithrombin anticoagulant function -- Implications for improved heparin anticoagulants.
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Mode of access: World Wide Web.