Structural basis for Fibroblast Growth Factor (FGF) receptor activation [electronic resource] : implications in development and disease / Moosa Mohammadi.
Material type:
FilmSeries: Henry Stewart talksBiomedical & life sciences collection. Signal transduction via protein tyrosine kinase receptors : structures, function, regulation, mechanisms and role in disease: Publisher: London : Henry Stewart Talks, 2007Description: 1 online resource (1 streaming video file (41 min.) : color, sound)Other title: Title from publisher's web site: Structural biology of FGF signaling in human development and diseaseSubject(s): Receptor Protein-Tyrosine Kinases | Signal TransductionOnline resources: Click here to access online | Series Animated audio-visual presentation with synchronized narration.
Title from title frames.
Contents: FGF family of ligands, and FGF receptor (FGFR) subfamily of receptor tyrosine kinase superfamily -- The roles of FGF signaling in mammalian biology and diseases -- FGFR receptor alternative splicing and its essential role in epithelial-mesenchymal signaling loop, and organogenesis -- Structural mechanism by which FGF and heparan sulfate induce FGFR dimerization and activation on the cell surface -- A working model for FGFR autoinhibition -- Structural mechanisms by which FGF-FGFR binding specificity is achieved -- Structural basis for how alternative splicing regulates ligand-binding specificity of FGFRs -- Structural basis by which ligand-dependent pathogenic mutations in FGFR lead to receptor gain-of-function in human skeletal syndromes -- Structural basis by which alternative splicing regulates patterning ability of FGF8 in the brain.
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Mode of access: World Wide Web.