Education of NK cells [electronic resource] : disarming of autoreactive NK cells David H. Raulet.
Material type:
FilmSeries: Henry Stewart talksBiomedical & life sciences collection. Natural killer cell biology : natural killer cell-mediated immunity to pathogens and cancer: Publisher: London : Henry Stewart Talks, 2009Description: 1 online resource (1 streaming video file (46 min.) : color, sound)Other title: Title from publisher's web site. Disarming of autoreactive NK cellsSubject(s): Cytotoxicity, Immunologic | Killer Cells, Natural | NeoplasmsOnline resources: Click here to access online | Series Animated audio-visual presentation with synchonized narration.
Title from title frames.
Contents: NK cell "education" -- NK cells in normal animals attack cells that lack some or all self MHC class I molecules -- NK cells that lack inhibitory receptors for self MHC class I are rendered hyporesponsive and self tolerant -- Hyporesponsiveness of NK cells is induced by target cells lacking MHC I, as in a mixed chimera -- Responsiveness of NK cells varies depending on how many MHC I-specific receptors they express -- NK cell education ensures that NK cells are optimally responsive yet not autoreactive.
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Mode of access: World Wide Web.