Chemokines and their receptors [electronic resource] : their biology and therapeutic relevance / Amanda E. I. Proudfoot.
Material type:
FilmSeries: Henry Stewart talksBiomedical & life sciences collection. Cells of the innate immune system: ; Henry Stewart talksBiomedical & life sciences collection. Cytokines: Publisher: London : Henry Stewart Talks, 2012Description: 1 online resource (1 streaming video file (49 min.) : color, sound)Subject(s): Chemokines -- Receptors -- Effect of drugs on | Natural immunity | Chemokines -- physiology | Immunity, Innate | Receptors, Chemokine -- drug effects | Receptors, Chemokine -- physiologyOnline resources: Click here to access online | Series (Cytokines) | Series (Cells of the innate immune system) Animated audio-visual presentation with synchronized narration.
Title from title frames.
Contents: Chemokines are immune modulators regulating direction of cell migration -- Chemokine receptors are seven transmembrane (7TM) G protein-coupled receptors -- Chemokines need to bind to endothelial expressed proteoglycans for activity in vivo -- Excessive cell recruitment is a hallmark of inflammation -- 7TM receptors are highly druggable targets for the pharmaceutical industry -- Chemokine receptors are an essential co-receptor for HIV infectivity -- Nature uses chemokine binding proteins to iinhibit the chemokine system.
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Mode of access: World Wide Web.