Discovery of Levetiracetam (Keppra(R)) [electronic resource] : the first SV2A ligand for the treatment of epilepsy / Henrik Klitgaard.
Material type:
FilmSeries: Henry Stewart talksBiomedical & life sciences collection. Drug discovery and development in the neurosciences: ; Henry Stewart talksBiomedical & life sciences collection. Small molecule drug discovery: Publisher: London : Henry Stewart Talks, 2013Description: 1 online resource (1 streaming video file (35 min.) : color, sound)Subject(s): Anticonvulsants | Convulsions -- Chemotherapy | Drug development | Epilepsy -- Chemotherapy | Anticonvulsants -- pharmacology | Anticonvulsants -- therapeutic use | Drug Discovery | Epilepsy -- drug therapy | Molecular Targeted Therapy | Piracetam -- pharmacology | Seizures -- drug therapyOnline resources: Click here to access online | Series (Drug discovery and development in the neurosciences) | Series (Small molecule drug discovery) Animated audio-visual presentation with synchronized narration.
Title from title frames.
Contents: Levetiracetam -- Antiepileptic Drug Discovery -- Levetiracetam in electroshock and PTZ seizures -- Protection against seizures in rat model -- Levetiracetam activity in GAERS model -- Impact on cognitive function -- Hyper-synchronization / excitability inhibition in vitro -- Effect on development of amygdala kindling -- Effect on seizures in genetic models of epilepsy -- Inactivation of sodium channels -- Reduction of current through T-type Ca channels -- Levetiracetam mechanism of action -- SV2 proteins: candidates for the LEV binding site -- SV2A cloning and binding studies -- Levetiracetam studies in SV2A (+/-) mice -- Profile of new class of antiepileptic drugs.
Access restricted to subscribers.
Mode of access: World Wide Web.