Klitgaard, Henrik.
Discovery of Levetiracetam (Keppra(R)) the first SV2A ligand for the treatment of epilepsy / [electronic resource] : Henrik Klitgaard. - London : Henry Stewart Talks, 2013. - 1 online resource (1 streaming video file (35 min.) : color, sound). - Drug discovery and development in the neurosciences, 2056-452X Small molecule drug discovery, 2056-452X . - Henry Stewart talks. Biomedical & life sciences collection. Drug discovery and development in the neurosciences. Henry Stewart talks. Biomedical & life sciences collection. Small molecule drug discovery. .
Animated audio-visual presentation with synchronized narration. Title from title frames.
Contents: Levetiracetam -- Antiepileptic Drug Discovery -- Levetiracetam in electroshock and PTZ seizures -- Protection against seizures in rat model -- Levetiracetam activity in GAERS model -- Impact on cognitive function -- Hyper-synchronization / excitability inhibition in vitro -- Effect on development of amygdala kindling -- Effect on seizures in genetic models of epilepsy -- Inactivation of sodium channels -- Reduction of current through T-type Ca channels -- Levetiracetam mechanism of action -- SV2 proteins: candidates for the LEV binding site -- SV2A cloning and binding studies -- Levetiracetam studies in SV2A (+/-) mice -- Profile of new class of antiepileptic drugs.
Access restricted to subscribers.
Mode of access: World Wide Web.
3569 Henry Stewart Talks
Anticonvulsants.
Convulsions--Chemotherapy.
Drug development.
Epilepsy--Chemotherapy.
Anticonvulsants--pharmacology.
Anticonvulsants--therapeutic use.
Drug Discovery.
Epilepsy--drug therapy.
Molecular Targeted Therapy.
Piracetam--pharmacology.
Seizures--drug therapy.
Discovery of Levetiracetam (Keppra(R)) the first SV2A ligand for the treatment of epilepsy / [electronic resource] : Henrik Klitgaard. - London : Henry Stewart Talks, 2013. - 1 online resource (1 streaming video file (35 min.) : color, sound). - Drug discovery and development in the neurosciences, 2056-452X Small molecule drug discovery, 2056-452X . - Henry Stewart talks. Biomedical & life sciences collection. Drug discovery and development in the neurosciences. Henry Stewart talks. Biomedical & life sciences collection. Small molecule drug discovery. .
Animated audio-visual presentation with synchronized narration. Title from title frames.
Contents: Levetiracetam -- Antiepileptic Drug Discovery -- Levetiracetam in electroshock and PTZ seizures -- Protection against seizures in rat model -- Levetiracetam activity in GAERS model -- Impact on cognitive function -- Hyper-synchronization / excitability inhibition in vitro -- Effect on development of amygdala kindling -- Effect on seizures in genetic models of epilepsy -- Inactivation of sodium channels -- Reduction of current through T-type Ca channels -- Levetiracetam mechanism of action -- SV2 proteins: candidates for the LEV binding site -- SV2A cloning and binding studies -- Levetiracetam studies in SV2A (+/-) mice -- Profile of new class of antiepileptic drugs.
Access restricted to subscribers.
Mode of access: World Wide Web.
3569 Henry Stewart Talks
Anticonvulsants.
Convulsions--Chemotherapy.
Drug development.
Epilepsy--Chemotherapy.
Anticonvulsants--pharmacology.
Anticonvulsants--therapeutic use.
Drug Discovery.
Epilepsy--drug therapy.
Molecular Targeted Therapy.
Piracetam--pharmacology.
Seizures--drug therapy.