Influence of eicosanoid lipid mediators on macrophage innate immune functions [electronic resource] / Marc Peters-Golden.
Material type:
FilmSeries: Henry Stewart talksBiomedical & life sciences collection. Macrophage heterogeneity and function: Publisher: London : Henry Stewart Talks, 2014Description: 1 online resource (1 streaming video file (60 min.) : color, sound)Subject(s): Eicosanoids | Macrophages | Natural immunity | Eicosanoids -- metabolism | Immunity, Innate -- immunology | MacrophagesOnline resources: Click here to access online | Series Animated audio-visual presentation with synchronized narration.
Title from title frames.
Contents: Mediator paradigms in innate immunity -- Eicosanoids -- Eicosanoids in antimicrobial immunity: Yin and Yang -- The leukotriene synthetic pathway -- Role of LTB4 in bacterial killing by AMs -- Pathway for NFκB activation upon PRR ligation -- Cross-talk between PRR and GPCR pathways? -- Dectin-1 -- LTB4 enhances yeast binding via dectin-1 -- Basal dectin-1 expression depends on constitutive LTB4 generation -- LTB4 enhances dectin-1-induced cytokine generation by elicited MΦ -- Dectin-1 expression in MΦ depends on an LTB4-PU.1 axis -- Pathway for NFκB activation upon TLR ligation -- LPS-induced nuclear translocation of NFκB subunits requires endogenous LTB4/BLT1 signaling -- 5-LO metabolism is required for MyD88-dependent NFkB activity in macrophages -- 5-LO and LTB4 are required for basal MyD88 expression in macrophages -- MyD88 expression is controlled by STAT-1 and SOCS1 -- SOCS1 siRNA restores MyD88 expression and LPS responsiveness in 5-LO -/- MΦs -- PGE2 actions are context-dependent -- PGE2 synthesis and signaling -- Opposing actions of PGE2 vs. LTB4 -- Eicosanoid imbalance in states of immunosuppression.
Access restricted to subscribers.
Mode of access: World Wide Web.