Peters-Golden, Marc,
Influence of eicosanoid lipid mediators on macrophage innate immune functions [electronic resource] / Marc Peters-Golden. - London : Henry Stewart Talks, 2014. - 1 online resource (1 streaming video file (60 min.) : color, sound). - Macrophage heterogeneity and function : role in innate and adaptive immunity, 2056-452X . - Henry Stewart talks. Biomedical & life sciences collection. Macrophage heterogeneity and function. .
Animated audio-visual presentation with synchronized narration. Title from title frames.
Contents: Mediator paradigms in innate immunity -- Eicosanoids -- Eicosanoids in antimicrobial immunity: Yin and Yang -- The leukotriene synthetic pathway -- Role of LTB4 in bacterial killing by AMs -- Pathway for NFκB activation upon PRR ligation -- Cross-talk between PRR and GPCR pathways? -- Dectin-1 -- LTB4 enhances yeast binding via dectin-1 -- Basal dectin-1 expression depends on constitutive LTB4 generation -- LTB4 enhances dectin-1-induced cytokine generation by elicited MΦ -- Dectin-1 expression in MΦ depends on an LTB4-PU.1 axis -- Pathway for NFκB activation upon TLR ligation -- LPS-induced nuclear translocation of NFκB subunits requires endogenous LTB4/BLT1 signaling -- 5-LO metabolism is required for MyD88-dependent NFkB activity in macrophages -- 5-LO and LTB4 are required for basal MyD88 expression in macrophages -- MyD88 expression is controlled by STAT-1 and SOCS1 -- SOCS1 siRNA restores MyD88 expression and LPS responsiveness in 5-LO -/- MΦs -- PGE2 actions are context-dependent -- PGE2 synthesis and signaling -- Opposing actions of PGE2 vs. LTB4 -- Eicosanoid imbalance in states of immunosuppression.
Access restricted to subscribers.
Mode of access: World Wide Web.
3541 Henry Stewart Talks
Eicosanoids.
Macrophages.
Natural immunity.
Eicosanoids--metabolism.
Immunity, Innate--immunology.
Macrophages.
Influence of eicosanoid lipid mediators on macrophage innate immune functions [electronic resource] / Marc Peters-Golden. - London : Henry Stewart Talks, 2014. - 1 online resource (1 streaming video file (60 min.) : color, sound). - Macrophage heterogeneity and function : role in innate and adaptive immunity, 2056-452X . - Henry Stewart talks. Biomedical & life sciences collection. Macrophage heterogeneity and function. .
Animated audio-visual presentation with synchronized narration. Title from title frames.
Contents: Mediator paradigms in innate immunity -- Eicosanoids -- Eicosanoids in antimicrobial immunity: Yin and Yang -- The leukotriene synthetic pathway -- Role of LTB4 in bacterial killing by AMs -- Pathway for NFκB activation upon PRR ligation -- Cross-talk between PRR and GPCR pathways? -- Dectin-1 -- LTB4 enhances yeast binding via dectin-1 -- Basal dectin-1 expression depends on constitutive LTB4 generation -- LTB4 enhances dectin-1-induced cytokine generation by elicited MΦ -- Dectin-1 expression in MΦ depends on an LTB4-PU.1 axis -- Pathway for NFκB activation upon TLR ligation -- LPS-induced nuclear translocation of NFκB subunits requires endogenous LTB4/BLT1 signaling -- 5-LO metabolism is required for MyD88-dependent NFkB activity in macrophages -- 5-LO and LTB4 are required for basal MyD88 expression in macrophages -- MyD88 expression is controlled by STAT-1 and SOCS1 -- SOCS1 siRNA restores MyD88 expression and LPS responsiveness in 5-LO -/- MΦs -- PGE2 actions are context-dependent -- PGE2 synthesis and signaling -- Opposing actions of PGE2 vs. LTB4 -- Eicosanoid imbalance in states of immunosuppression.
Access restricted to subscribers.
Mode of access: World Wide Web.
3541 Henry Stewart Talks
Eicosanoids.
Macrophages.
Natural immunity.
Eicosanoids--metabolism.
Immunity, Innate--immunology.
Macrophages.