Pathogenic mechanisms in prion disease [electronic resource] / Giovanna Mallucci.
Material type:
FilmSeries: Henry Stewart talksBiomedical & life sciences collection. Genetic basis of neurological disorders: Publisher: London : Henry Stewart Talks, 2014Description: 1 online resource (1 streaming video file (32 min.) : color, sound)Subject(s): Nervous system -- Degeneration | Nervous system -- Diseases -- Genetic aspects | Prion diseases | Protein folding | Proteins -- Metabolism -- Disorders | Neurodegenerative Diseases | Prion Diseases | Protein Folding | Proteostasis Deficiencies | Unfolded Protein ResponseOnline resources: Click here to access online | Series Animated audio-visual presentation with synchronized narration.
Title from title frames.
Contents: Neurodegenerative diseases and protein misfolding disorders -- Prion disease in mice to study mechanisms of neurodegeneration due to misfolded protein accumulation -- Early prion neurodegenerative change is reversible: access to key neurotoxic pathways -- Critical change is loss of synaptic proteins due to activation of PERK branch of the unfolded protein response -- Modifying this pathway genetically is neuroprotective -- Modifying this pathway pharmacologically is neuroprotective -- Relevance of this pathway in other neurodegenerative diseases with misolded proteins e.g. Alzheimer's and Parkinson's and ALS -- Relevance in learning and memory -- Common target for therapy in these disorders.
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Mode of access: World Wide Web.