Mallucci, Giovanna,
Pathogenic mechanisms in prion disease [electronic resource] / Giovanna Mallucci. - London : Henry Stewart Talks, 2014. - 1 online resource (1 streaming video file (32 min.) : color, sound). - The genetic basis of neurological disorders, 2056-452X . - Henry Stewart talks. Biomedical & life sciences collection. Genetic basis of neurological disorders. .
Animated audio-visual presentation with synchronized narration. Title from title frames.
Contents: Neurodegenerative diseases and protein misfolding disorders -- Prion disease in mice to study mechanisms of neurodegeneration due to misfolded protein accumulation -- Early prion neurodegenerative change is reversible: access to key neurotoxic pathways -- Critical change is loss of synaptic proteins due to activation of PERK branch of the unfolded protein response -- Modifying this pathway genetically is neuroprotective -- Modifying this pathway pharmacologically is neuroprotective -- Relevance of this pathway in other neurodegenerative diseases with misolded proteins e.g. Alzheimer's and Parkinson's and ALS -- Relevance in learning and memory -- Common target for therapy in these disorders.
Access restricted to subscribers.
Mode of access: World Wide Web.
3786 Henry Stewart Talks
Nervous system--Degeneration.
Nervous system--Diseases--Genetic aspects.
Prion diseases.
Protein folding.
Proteins--Metabolism--Disorders.
Neurodegenerative Diseases.
Prion Diseases.
Protein Folding.
Proteostasis Deficiencies.
Unfolded Protein Response.
Pathogenic mechanisms in prion disease [electronic resource] / Giovanna Mallucci. - London : Henry Stewart Talks, 2014. - 1 online resource (1 streaming video file (32 min.) : color, sound). - The genetic basis of neurological disorders, 2056-452X . - Henry Stewart talks. Biomedical & life sciences collection. Genetic basis of neurological disorders. .
Animated audio-visual presentation with synchronized narration. Title from title frames.
Contents: Neurodegenerative diseases and protein misfolding disorders -- Prion disease in mice to study mechanisms of neurodegeneration due to misfolded protein accumulation -- Early prion neurodegenerative change is reversible: access to key neurotoxic pathways -- Critical change is loss of synaptic proteins due to activation of PERK branch of the unfolded protein response -- Modifying this pathway genetically is neuroprotective -- Modifying this pathway pharmacologically is neuroprotective -- Relevance of this pathway in other neurodegenerative diseases with misolded proteins e.g. Alzheimer's and Parkinson's and ALS -- Relevance in learning and memory -- Common target for therapy in these disorders.
Access restricted to subscribers.
Mode of access: World Wide Web.
3786 Henry Stewart Talks
Nervous system--Degeneration.
Nervous system--Diseases--Genetic aspects.
Prion diseases.
Protein folding.
Proteins--Metabolism--Disorders.
Neurodegenerative Diseases.
Prion Diseases.
Protein Folding.
Proteostasis Deficiencies.
Unfolded Protein Response.