Protein degradation and defense against neurodegenerative disease [electronic resource] : part 2 of 2 / Alfred Goldberg.
Material type:
FilmSeries: Henry Stewart talksBiomedical & life sciences collection. Protein homeostasis: Publisher: London : Henry Stewart Talks, 2014Description: 1 online resource (1 streaming video file (42 min.) : color, sound)Other title: Protein degradation and defense against neurodegenerative disease part 2 of 2Subject(s): Brain -- Aging -- Molecular aspects | Nervous system -- Degeneration | Protein folding | Proteins -- Metabolism | Ubiquitin | Neurodegenerative Diseases -- metabolism | Proteasome Endopeptidase Complex | Proteasome Inhibitors | Protein Folding | Proteins -- chemistry | Proteins -- metabolism | Proteolysis | Ubiquitin -- metabolismOnline resources: Click here to access online | Series Animated audio-visual presentation with synchronized narration.
Title from title frames.
Contents: The 26S proteasome -- The 20S proteasome -- Proteasome inhibitors -- PS-341 -- Proteasome inhibitors in multiple myeloma -- Structures of the archaeal PAN ATPase-20S complex and the eukaryotic 26S proteasome -- Multiple ATP-dependent steps in proteasome function -- The gating mechanism of the proteasome -- Prions inhibit proteasome function -- Binding of ubiquitin conjugates activate the 26S proteasome by stimulating 20S gate-opening and ATP hydrolysis -- Ubiquitin conjugates activate their own degradation by the 26S Proteasome -- The inhibitor of proteasome-associated deubiquitinating enzyme Usp14, IU1, enhances degradation of tau.
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Mode of access: World Wide Web.