Goldberg, Alfred,
Protein degradation and defense against neurodegenerative disease part 2 of 2 / [electronic resource] : Protein degradation and defense against neurodegenerative disease part 2 of 2 Alfred Goldberg. - London : Henry Stewart Talks, 2014. - 1 online resource (1 streaming video file (42 min.) : color, sound). - Protein homeostasis : folding proteins and maintaining the protein-protein interaction networks, 2056-452X . - Henry Stewart talks. Biomedical & life sciences collection. Protein homeostasis. .
Animated audio-visual presentation with synchronized narration. Title from title frames.
Contents: The 26S proteasome -- The 20S proteasome -- Proteasome inhibitors -- PS-341 -- Proteasome inhibitors in multiple myeloma -- Structures of the archaeal PAN ATPase-20S complex and the eukaryotic 26S proteasome -- Multiple ATP-dependent steps in proteasome function -- The gating mechanism of the proteasome -- Prions inhibit proteasome function -- Binding of ubiquitin conjugates activate the 26S proteasome by stimulating 20S gate-opening and ATP hydrolysis -- Ubiquitin conjugates activate their own degradation by the 26S Proteasome -- The inhibitor of proteasome-associated deubiquitinating enzyme Usp14, IU1, enhances degradation of tau.
Access restricted to subscribers.
Mode of access: World Wide Web.
3840 Henry Stewart Talks
Brain--Aging--Molecular aspects.
Nervous system--Degeneration.
Protein folding.
Proteins--Metabolism.
Ubiquitin.
Neurodegenerative Diseases--metabolism.
Proteasome Endopeptidase Complex.
Proteasome Inhibitors.
Protein Folding.
Proteins--chemistry.
Proteins--metabolism.
Proteolysis.
Ubiquitin--metabolism.
Protein degradation and defense against neurodegenerative disease part 2 of 2 / [electronic resource] : Protein degradation and defense against neurodegenerative disease part 2 of 2 Alfred Goldberg. - London : Henry Stewart Talks, 2014. - 1 online resource (1 streaming video file (42 min.) : color, sound). - Protein homeostasis : folding proteins and maintaining the protein-protein interaction networks, 2056-452X . - Henry Stewart talks. Biomedical & life sciences collection. Protein homeostasis. .
Animated audio-visual presentation with synchronized narration. Title from title frames.
Contents: The 26S proteasome -- The 20S proteasome -- Proteasome inhibitors -- PS-341 -- Proteasome inhibitors in multiple myeloma -- Structures of the archaeal PAN ATPase-20S complex and the eukaryotic 26S proteasome -- Multiple ATP-dependent steps in proteasome function -- The gating mechanism of the proteasome -- Prions inhibit proteasome function -- Binding of ubiquitin conjugates activate the 26S proteasome by stimulating 20S gate-opening and ATP hydrolysis -- Ubiquitin conjugates activate their own degradation by the 26S Proteasome -- The inhibitor of proteasome-associated deubiquitinating enzyme Usp14, IU1, enhances degradation of tau.
Access restricted to subscribers.
Mode of access: World Wide Web.
3840 Henry Stewart Talks
Brain--Aging--Molecular aspects.
Nervous system--Degeneration.
Protein folding.
Proteins--Metabolism.
Ubiquitin.
Neurodegenerative Diseases--metabolism.
Proteasome Endopeptidase Complex.
Proteasome Inhibitors.
Protein Folding.
Proteins--chemistry.
Proteins--metabolism.
Proteolysis.
Ubiquitin--metabolism.