Iron metabolism and innate immunity [electronic resource] / Tomas Ganz.
Material type:
FilmSeries: Henry Stewart talksBiomedical & life sciences collection. Innate immunity : host recognition and response in health and disease: Publisher: London : Henry Stewart Talks, 2020Description: 1 online resource (1 streaming video file (27 min.) : color, sound)Subject(s): Anemia | Hemochromatosis | Iron in the body | Iron -- Metabolism -- Disorder | Macrophages | Natural immunity | Anemia, Iron-Deficiency -- immunology | Hemochromatosis -- immunology | Hepcidins | Immunity, Innate | Inflammation -- complications | Iron -- metabolism | metal transporting protein 1Online resources: Click here to access online | Series Animated audio-visual presentation with synchronized narration.
Title from title frames.
Updated version of a talk first published in 2009.
Contents: Iron is an essential element for nearly all infectious microorganisms as well as for their plant and animal hosts -- Within hours of infection, animals sequester iron within macrophages as well as in specialized extracellular proteins -- The cellular component of this response causes a marked decrease in extracellular iron concentration -- Hepcidin is a recently characterized peptide that functions as the homeostatic iron-regulatory hormone and as the mediator of inflammatory iron sequestration -- It acts by binding to the sole known cellular iron exporter, ferroportin, and inducing its internalization and degradation -- Pathological regulation or dysregulation of the hepcidin-ferroportin axis is responsible for a number of common iron-related disorders including anemia of inflammation, hereditary hemochromatosis and iron-loading anemias.
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Mode of access: World Wide Web.