Ganz, Tomas,
Iron metabolism and innate immunity [electronic resource] / Tomas Ganz. - London : Henry Stewart Talks, 2020. - 1 online resource (1 streaming video file (27 min.) : color, sound). - Innate immunity : host recognition and response in health and disease, 2056-452X . - Henry Stewart talks. Biomedical & life sciences collection. Innate immunity : host recognition and response in health and disease. .
Animated audio-visual presentation with synchronized narration. Title from title frames. Updated version of a talk first published in 2009.
Contents: Iron is an essential element for nearly all infectious microorganisms as well as for their plant and animal hosts -- Within hours of infection, animals sequester iron within macrophages as well as in specialized extracellular proteins -- The cellular component of this response causes a marked decrease in extracellular iron concentration -- Hepcidin is a recently characterized peptide that functions as the homeostatic iron-regulatory hormone and as the mediator of inflammatory iron sequestration -- It acts by binding to the sole known cellular iron exporter, ferroportin, and inducing its internalization and degradation -- Pathological regulation or dysregulation of the hepcidin-ferroportin axis is responsible for a number of common iron-related disorders including anemia of inflammation, hereditary hemochromatosis and iron-loading anemias.
Access restricted to subscribers.
Mode of access: World Wide Web.
1979 Henry Stewart Talks
Anemia.
Hemochromatosis.
Iron in the body.
Iron--Metabolism--Disorder.
Macrophages.
Natural immunity.
Anemia, Iron-Deficiency--immunology.
Hemochromatosis--immunology.
Hepcidins.
Immunity, Innate.
Inflammation--complications.
Iron--metabolism.
metal transporting protein 1.
Iron metabolism and innate immunity [electronic resource] / Tomas Ganz. - London : Henry Stewart Talks, 2020. - 1 online resource (1 streaming video file (27 min.) : color, sound). - Innate immunity : host recognition and response in health and disease, 2056-452X . - Henry Stewart talks. Biomedical & life sciences collection. Innate immunity : host recognition and response in health and disease. .
Animated audio-visual presentation with synchronized narration. Title from title frames. Updated version of a talk first published in 2009.
Contents: Iron is an essential element for nearly all infectious microorganisms as well as for their plant and animal hosts -- Within hours of infection, animals sequester iron within macrophages as well as in specialized extracellular proteins -- The cellular component of this response causes a marked decrease in extracellular iron concentration -- Hepcidin is a recently characterized peptide that functions as the homeostatic iron-regulatory hormone and as the mediator of inflammatory iron sequestration -- It acts by binding to the sole known cellular iron exporter, ferroportin, and inducing its internalization and degradation -- Pathological regulation or dysregulation of the hepcidin-ferroportin axis is responsible for a number of common iron-related disorders including anemia of inflammation, hereditary hemochromatosis and iron-loading anemias.
Access restricted to subscribers.
Mode of access: World Wide Web.
1979 Henry Stewart Talks
Anemia.
Hemochromatosis.
Iron in the body.
Iron--Metabolism--Disorder.
Macrophages.
Natural immunity.
Anemia, Iron-Deficiency--immunology.
Hemochromatosis--immunology.
Hepcidins.
Immunity, Innate.
Inflammation--complications.
Iron--metabolism.
metal transporting protein 1.