The role of short linear motifs (SLiMs) in SARS-CoV-2 entry into human cells [electronic resource] / an interview with Toby Gibson.
Material type:
SoundSeries: Henry Stewart talksBiomedical & life sciences collection. Interviews on Covid-19: Publisher: London : Henry Stewart Talks, 2021Description: 1 online resource (1 streaming audio file (12 min.))Subject(s): Cell receptors | Coronaviruses | COVID-19 (Disease) -- Research | COVID-19 (Disease) -- Treatment | Drug development | Host-virus relationships | Viruses -- Receptors | Amino Acid Motifs | Angiotensin-Converting Enzyme 2 -- chemistry | Angiotensin-Converting Enzyme 2 -- physiology | Antiviral Agents | Chloroquine | Chlorpromazine | COVID-19 -- therapy | COVID-19 -- virology | Endocytosis | Host Microbial Interactions | Integrins -- chemistry | Integrins -- physiology | Models, Biological | Molecular Targeted Therapy | SARS-CoV-2 -- pathogenicity | SARS-CoV-2 -- physiology | Spike Glycoprotein, Coronavirus | Virus InternalizationOnline resources: Click here to access online | Series Audio interview.
Title from title frames.
Contents: Rationale and approach to investigating ACE2 and integrin SLiMs -- Update on the mechanism of ACE2- and integrin-mediated viral entry into cells -- SLiMs and their essential role in cellular endocytosis -- Possibility of targeting specific SLiMs as a novel antiviral therapy -- Efficacy of Chloroquine and Chlorpromazine as potential small-molecule therapeutics against viral entry into cells -- The power of interfering with integrin-dependent cellular endocytosis as a proactive defense against coronaviruses.
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Mode of access: World Wide Web.