The influence of variation at the killer cell immunoglobulin-like receptor gene complex on human disease [electronic resource] / Mary Carrington.
Material type:
FilmSeries: Henry Stewart talksBiomedical & life sciences collection. Natural killer cell biology : natural killer cell-mediated immunity to pathogens and cancer: Publisher: London : Henry Stewart Talks, 2021Description: 1 online resource (1 streaming video file (26 min.) : color, sound)Subject(s): Immunogenetics | Killer cells | Acquired Immunodeficiency Syndrome -- immunology | Arthritis, Psoriatic -- immunology | Autoimmune Diseases -- genetics | Genetic Variation | Hepatitis C -- immunology | HIV Infections -- immunology | Infections -- genetics | Infections -- immunology | Killer Cells, Natural -- immunology | Ligands | Maternal-Fetal Exchange -- immunology | Multigene Family | Neoplasms -- immunology | Pregnancy -- immunology | Receptors, Immunologic -- genetics | Receptors, Immunologic -- metabolism | Receptors, KIROnline resources: Click here to access online | Series Animated audio-visual presentation with synchronized narration.
Title from title frames.
Updated version of a talk first published in 2009.
Contents: Domain structure of human KIRs -- HLA class I and KIR -- Stochastic expression of KIR genes -- HLA ligands for KIRs -- KIR polymorphism -- KIR disease associations: autoimmune, maternal-fetal, cancer and infectious -- NK cell activation probably enhances HCV clearance -- NK cell activation probably protects against persistent HCV infection, reproductive failure and early after HIV infection AIDS progression -- NK cell inhibition probably protects against psoriatic arthritis and cervical neoplasia -- Striking a balance between activating and inhibitory KIR genotypes.
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Mode of access: World Wide Web.