Chromosome bi-orientation in yeast [electronic resource] / Mike Stark and Tomo Tanaka.
Material type:
FilmSeries: Henry Stewart talksBiomedical & life sciences collection. Cell division cycle : controlling when and where cells divide and differentiate: Publisher: London : Henry Stewart Talks, 2022Description: 1 online resource (1 streaming video file (54 min.) : color, sound)Subject(s): Saccharomyces cerevisiae -- Genetics | Yeast fungi -- Genetics | Aneuploidy | Aurora Kinases | Cell Cycle | Chromatids | Chromosomes, Fungal | Kinetochores | Microtubules | Saccharomyces cerevisiae -- genetics | Saccharomyces cerevisiae -- physiology | Spindle Apparatus -- physiologyOnline resources: Click here to access online | Series Animated audio-visual presentation with synchronized narration.
Title from title frames.
Updated version of a talk first published in 2009.
Contents: What is chromosome biorientation and why is it important? -- Failure to bi-orient a chromosome will lead to mis-segregation/aneuploidy -- Modes of sister chromatid attachment to spindle microtubules -- The budding yeast (Saccharomyces cerevisiae) as a model for studying chromosome bi-orientation -- Monitoring sister centromeres on individual yeast chromosomes -- Kinetochore capture -- Achieving chromosome bi-orientation: mechanisms -- Geometry-dependent mechanism or a correction mechanism? -- Yeast Ipl1p kinase -- Chromosomes fail to bi-orient with high frequency in Ipl1 mutants -- How might Ipl1p kinase promote bi-orientation? -- Yeast chromosomes can bi-orient without the need for back-to-back geometry -- How does Ipl1p kinase promote bi-orientation? -- The yeast chromosomal passenger complex -- Models for tension-sensing -- What are the targets of Ipl1p kinase at the kinetochore? -- Model for Ipl1 / Aurora function in promoting bi-orientation -- Does Aurora B have similar targets in other organisms? -- Other components required for bi-orientation -- Ipl1p kinase may coordinate chromosome bi-orientation and spindle checkpoint activation.
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Mode of access: World Wide Web.