Genetic polymorphism of thiopurine methyltransferase and thiopurine therapy [electronic resource] : from molecular genetics to clinical medicine / William E. Evans.
Material type:
Animated audio-visual presentation with synchronized narration.
Title from title frames.
Updated version of a talk first published in 2009.
Contents: Pharmacogenomics to optimize cancer chemotherapeutics -- The genetic polymorphism of thiopurine methyltransferase (TPMT) -- Its influence on thiopurine (e.g., mercaptopurine, azathioprine) therapy -- Molecular and biochemical basis of this pharmacogenetic trait -- Clinical diagnostic widely used to individualize and optimize thiopurine therapy for cancer and other diseases -- Update talk: Hematologic toxicity of thiopurines -- Update talk: TPMT -- Update talk: NUDT15 -- Update talk: Ancestry-related differences in allele frequency.
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Mode of access: World Wide Web.