Genetic polymorphism of thiopurine methyltransferase and thiopurine therapy [electronic resource] : from molecular genetics to clinical medicine / William E. Evans.Material type: FilmSeries: Henry Stewart talksBiomedical & life sciences collection. Cancer therapy : latest thinking in efficacy and toxicity: Publisher: London : Henry Stewart Talks, 2022Description: 1 online resource (1 streaming video file (55 min.) : color, sound)Subject(s): Cancer -- Chemotherapy | Methyltransferases | Molecular genetics | Pharmacogenomics | Azathioprine | Gene Frequency | Mercaptopurine | Methyltransferases -- genetics | Methyltransferases -- metabolism | Molecular Biology | Neoplasms -- complications | Neoplasms -- drug therapy | Pharmacogenetics | Pharmacogenomic Testing | Polymorphism, Genetic | thiopurine methyltransferaseOnline resources: Click here to access online | Series
Animated audio-visual presentation with synchronized narration.
Title from title frames.
Updated version of a talk first published in 2009.
Contents: Pharmacogenomics to optimize cancer chemotherapeutics -- The genetic polymorphism of thiopurine methyltransferase (TPMT) -- Its influence on thiopurine (e.g., mercaptopurine, azathioprine) therapy -- Molecular and biochemical basis of this pharmacogenetic trait -- Clinical diagnostic widely used to individualize and optimize thiopurine therapy for cancer and other diseases -- Update talk: Hematologic toxicity of thiopurines -- Update talk: TPMT -- Update talk: NUDT15 -- Update talk: Ancestry-related differences in allele frequency.
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Mode of access: World Wide Web.