Evans, William E.

Genetic polymorphism of thiopurine methyltransferase and thiopurine therapy from molecular genetics to clinical medicine / [electronic resource] : William E. Evans. - London : Henry Stewart Talks, 2022. - 1 online resource (1 streaming video file (55 min.) : color, sound). - Cancer therapy : latest thinking in efficacy and toxicity , 2056-452X . - Henry Stewart talks. Biomedical & life sciences collection. Cancer therapy : latest thinking in efficacy and toxicity. .

Animated audio-visual presentation with synchronized narration. Title from title frames. Updated version of a talk first published in 2009.

Contents: Pharmacogenomics to optimize cancer chemotherapeutics -- The genetic polymorphism of thiopurine methyltransferase (TPMT) -- Its influence on thiopurine (e.g., mercaptopurine, azathioprine) therapy -- Molecular and biochemical basis of this pharmacogenetic trait -- Clinical diagnostic widely used to individualize and optimize thiopurine therapy for cancer and other diseases -- Update talk: Hematologic toxicity of thiopurines -- Update talk: TPMT -- Update talk: NUDT15 -- Update talk: Ancestry-related differences in allele frequency.

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Mode of access: World Wide Web.

2012 Henry Stewart Talks

Molecular genetics.
Gene Frequency.
Molecular Biology.
Neoplasms--drug therapy.
Pharmacogenomic Testing.
Polymorphism, Genetic.
thiopurine methyltransferase.
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