Dickenson, A. H.

Receptors and channels in pain [electronic resource] / Tony Dickenson. - London : Henry Stewart Talks, 2014. - 1 online resource (1 streaming video file (45 min.) : color, sound). - Synapses, neurotransmitters and receptor channels, 2056-452X . - Henry Stewart talks. Biomedical & life sciences collection. Synapses, neurotransmitters and receptor channels. .

Animated audio-visual presentation with synchronized narration. Title from title frames.

Contents: CNS pain circuits -- Receptors, ligands , mediators & ion channels involved in pain signaling -- Key types of pain -- Inflammation (ongoing activation of pain sensors) -- Nerve growth factor and bone innervation -- Tanezumab: humanized monoclonal antibody -- Symptoms of neuropathic pain -- Sodium channel changes, redistribution, activation -- Channelopathic pain syndromes -- Pregabalin and gabapentin -- Ca channels -- Peripheral activity causes central hyperexcitability -- Post-synaptic neuron activation -- Spinal mechanisms -- NMDA receptors -- Central sensitization -- Noradrenaline and 5HT -- Pain sensitivity: pathway alterations -- Reduced NA\increased 5HT function: effects -- Diffuse Noxious Inhibitory Controls (DNIC) -- Morphine and codeine -- Opioid mechanisms -- Pain signaling, multi-level changes & drug targets -- Similar symptoms\signs: many mechanisms.

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Mode of access: World Wide Web.

3615 Henry Stewart Talks


Analgesia.
Central nervous system--Physiology.
Ion channels.
Nociceptors.
Pain.
Synapses--Physiology.
Analgesics--pharmacology.
Analgesics--therapeutic use.
Central Nervous System--physiology.
Ion Channels--physiology.
Nociceptors--drug effects.
Nociceptors--physiopathlogy.
Pain--drug therapy.
Pain--physiopathology.
Receptors, Neurotransmitter.
Synapses--physiology.
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