Receptors and channels in pain [electronic resource] / Tony Dickenson.
Material type:
FilmSeries: Henry Stewart talksBiomedical & life sciences collection. Synapses, neurotransmitters and receptor channels: Publisher: London : Henry Stewart Talks, 2014Description: 1 online resource (1 streaming video file (45 min.) : color, sound)Subject(s): Analgesia | Central nervous system -- Physiology | Ion channels | Nociceptors | Pain | Synapses -- Physiology | Analgesics -- pharmacology | Analgesics -- therapeutic use | Central Nervous System -- physiology | Ion Channels -- physiology | Nociceptors -- drug effects | Nociceptors -- physiopathlogy | Pain -- drug therapy | Pain -- physiopathology | Receptors, Neurotransmitter | Synapses -- physiologyOnline resources: Click here to access online | Series Animated audio-visual presentation with synchronized narration.
Title from title frames.
Contents: CNS pain circuits -- Receptors, ligands , mediators & ion channels involved in pain signaling -- Key types of pain -- Inflammation (ongoing activation of pain sensors) -- Nerve growth factor and bone innervation -- Tanezumab: humanized monoclonal antibody -- Symptoms of neuropathic pain -- Sodium channel changes, redistribution, activation -- Channelopathic pain syndromes -- Pregabalin and gabapentin -- Ca channels -- Peripheral activity causes central hyperexcitability -- Post-synaptic neuron activation -- Spinal mechanisms -- NMDA receptors -- Central sensitization -- Noradrenaline and 5HT -- Pain sensitivity: pathway alterations -- Reduced NA\increased 5HT function: effects -- Diffuse Noxious Inhibitory Controls (DNIC) -- Morphine and codeine -- Opioid mechanisms -- Pain signaling, multi-level changes & drug targets -- Similar symptoms\signs: many mechanisms.
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Mode of access: World Wide Web.